Melanated People

3 yrs

😊😊😊

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3 yrs

Hamar people are a community inhabiting southwestern Ethiopia 🇪🇹. They live in Hamer Woreda a fertile part of the Omo River valley, in the Debub Omo Zone of the SouthernNations. They are largely pastoralists, so their culture places a high value on cattle. In the tradition known as Ukuli Bula, women are whipped as part of a Rite of Passage ceremony for boys, When female family members declare their love for the young man at the heart of the celebration. The boy is then allowed to marry since the ceremony makes him a man. A key element of the ceremony is the whipping of young women who are family members or relatives of the boy undertaking the Rite-of-Passage.The women dance and sing, extolling the virtues of the Jumper, declaring their love for him and for their desire to be marked by the whip. The women instead of fleeing beg men to whip them again during the ceremony held in the Omo River Valley. Once whipped, the girls proudly show off their scars as a proof of their courage and integrity. Some whipping appears to be tender, others more fierce.They coat their bodies with butter to lessen the effect of the whipping which is only carried out by Maza - those who have already undergone this Rite-of-Passage.

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3 yrs

If you celebrating today. Have fun do you. If you arent, have fun do you

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3 yrs

America

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3 yrs

I'll leave this right here...

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3 yrs

I am delighted to share our latest paper where we show aging is likely driven by changes to the epigenome, a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot. The data supports The Information Theory of Aging, which you may know about from Lifespan, the book.
The mouse on the left had its epigenome destabilized so that it aged 50% faster. Then we reversed it...
If we are correct, it means that cancer, diabetes and Alzheimer's might have the same underlying cause that can be reversed to treat or cure age-related conditions with a single treatment. Experiments in the lab are testing this.
Genetic information is the hardware and the epigenome is the software (the pink protein balls in the image that spool DNA).
We think aging is due to corrupted software, that can be rebooted to restore youth. We show DNA breaks cause the software to become corrupted. We experience DNA breaks by the trillions every day & these advance the biological clock. The age-reversal technology -- which turns on an embryonic gene program -- is being tested at life biosciences in non-human primates to restore vision. Results out in a few months. The work represents 13 years of work by 60 people in my lab and around the world. Great work by Jay-Hyun Yang, lead scientist and 1st author. We also stand on the shoulders of greats - Lenny Guarente, Eric Verdin, Nir Barzilai, Matt Kaeberlein, Brian Kennedy, Jasper Rine, Steve Helfand, Steve Horvath, John Denu, Rafa de Cabo.
Can this age reversal tech extend lifespan? This week David Sohn and colleagues showed our exact system extends lifespan in very old mice, when initiated at the human equivalent age of 70-80! I suspect the rejuvenation process exists in salamanders and reptiles but we have lost this ability (for now).
We dedicate this paper to coauthors Michael Bonkowski (last photo), Norman Wolf, and our patriarch Paul F Glenn, who we lost on this journey. Thanks to all our financial supporters & members of the Sinclair laboratory, past & present